AIDS endure the phrase for Acquired Immune-Deficiency Syndrome whatever it is an incurable disease in which CD4 cells bit lower 200 cells/mm3 of blood. Its aggressive progression and massive impact on mankind are still frightening. AIDS is the most crucial popular health issues of the slow twentieth and initial twenty- first ventures and is now one of the well-known element of global morbidity and mortality. The two molecules on the HIV-1 envelope, the external glycoprotein (gp120) and the transmembrane protein (gp41), form the prick on the virion’s surface 25. During the entry process, gp120 attaches to the cell membrane by first binding to the CD4+ receptor. Fascinating evidence from non-human primate models (e.g., simian immunodeficiency virus [SIV] infection of rhesus macaques) suggest that vaginal transmission results in infection of a small number of CD4+ T lymphocytes, macrophages and dendritic cells located in the lamina propria. Probable pathways for virus transmission involve endocytosis, transcytosis, and virus attachment to mannose C-type lectin receptors (e.g., DC-SIGN) located on dendritic cells and macrophages. ELISA or Enzyme-Linked Immuno-Sorbent Assay is the first test that is carried out to detect HIV. It is efficient of detecting the presence of antibodies to both HIV 1 and HIV 2 virus. It can detect recent infection much earlier than other tests distinguish only antibodies (up to 14 days after exposure). Treatment is anti-retroviral therapy.