This chapter is all about, to know the various Biological factors that affect an individual’s physical activities. And determine the growth and development of a person. Though the nature has provided the base to human physique and its functioning but even environment also has a great influence on individual’s growth and development. Through this chapter try to understand the importance for an individual to inherit the well-organized structure for efficient functioning, but if this structure is not nurtured carefully there may be lots of complications arise in growth and development, Physical activities as well mental process negatively. Also, the importance of Physical activities in relation to fitness, emotional and mental outlet. This chapter will definitely enlighten that how biological evolution has brought an inheritance of structure and function that require care and attention. As the artificial situation developed by modern civilisation has affected the society in many ways. Sound mind would require a sound body.