Since the beginning of human civilization, people have utilised plants as both preventative and therapeutic agents. Folklorists have utilised a wide range of unprocessed medicinal plants to treat a wide range of illnesses. Pharmaceuticals such as digitoxin, reserpine, ephedrine, ergometrine, atropine, and vinblastine, to mention a few, have long been found in plants. In many nations, the use of ethnobotanical information has been crucial to the discovery of new drugs. Therefore, the future development of drugs will be significantly impacted by the loss of this indigenous expertise. Up to now, the primary focus of biological activity screening has been on antibacterial, antioxidant capacity, anti-cancer, and associated criteria. Research has shown that indigenous people utilise natural remedies to prevent snake poison from killing them. The current chapter supports the potential of ethnopharmacology as a tool for developing effective inhibitors or formulation of herbal medicines against venom toxins, especially local tissue damage, by providing a modernised scenario and insights into future research aiming at validating medicinal plants as antiophidic agents.