Strawberries, an expensive source of phytochemicals (ellagic acid, anthocyanins, quercetin, and catechin) and vitamins (ascorbic acid and folic acid), are highly ranked among dietary sources of polyphenols and antioxidant capacity. It belongs to the Rosaceae family. The potential health benefits related to dietary intake of fruits have attracted increasing interest. Among berries, the strawberry may be a rich source of several nutritive and nonnutritive bioactive compounds, which are implicated in various health promoting and disease preventive effects. A plethora of studies have examined the advantages of strawberry consumption, like prevention of inflammation disorders and oxidative stress, reduction of obesity related disorders and cardiovascular disease risk, and protection against various varieties of cancer. This chapter provides an summary of their nutritional and medicinal benefits and which factors enhance their content in strawberries. In addition, the bioavailability and metabolism of major strawberry phytochemicals in addition as their actions in combating many pathologies, including cancer, metabolic syndrome, cardiovascular disease, obesity, diabetes, neurodegeneration, together with microbial pathogenesis have been analysed very well, with a particular attention to human studies. The strawberry (Fragaria ananassa) represents a relevant source of micronutrients, like minerals, vitamin C, folate and phenolic substances, most of which are natural antioxidants and contribute to the high nutritional quality of the fruit. All these compounds are essential for health and, specifically, strawberry phenolics are best known for his or her antioxidant and antiinflammatory action, and possess directly and indirectly antimicrobial, antiallergic and hypotensive properties, further because the ability to inhibit the activity of variety of physiological enzymes and receptor properties. The most objective of this chapter is to review and update current knowledge on the potential effects of strawberries on human health, with particular attention to its compounds and possible mechanisms of action.