Though the technology for developing virus-immune transgenic plants by using the coat protein of a virus was first reported 20 years ago, it is surprising to note that only a three such virus-resistant plants (squash, potato and papaya) have been commercialized in the United States. The GE papaya cultivars Rainbow and Sun- Up were released commercially in Hawaii in 1998 and virtually saved Hawaii’s papaya industry from the devastation being caused by Papaya ringspot virus (PRSV). This chapter focuses on the development, release and impact of the PRSV-immune transgenics. Primary consideration is given to the factors that affected the timely growth and deployment, rather than specifics on the technical aspects of the GE papaya. Our efforts to transfer the technology to Jamaica, Venezuela and Thailand are described to point out the factors that have influenced the practical deployment of the transgenic papaya to countries outside the United States. Finally, production, uses and benefits of transgenic papaya are discussed.