Weeds are one of the most significant constraints in agriculture. The emergence of weeds in crop fields paved the way for the application of broad-spectrum chemical or synthetic herbicides as a method of weed management. Weed management has changed considerably with the widespread use of herbicide-resistant (HR) crops. The adoption of HR crops in agriculture has enabled the rapid transitioning of the agricultural sector from a chemistry-based to a biotechnology-oriented sector. The crops made resistant to herbicides biotechnologically are being widely used in many parts of the world, both transgenic and non-transgenic and have been produced and commercialized. These HR crops often allayed growers' fears about crop damage and gave them the freedom to use new herbicides with increased weed activity and ecological sustainability. This technological innovation and advancement have a significant influence on agriculture, weed management systems, the pesticide sector, and weed science. Herbicide resistance in several crop species has been achieved through both traditional breeding and genetic engineering techniques. Weed management strategies are further enhanced by the introduction of multiple herbicide-resistant crops. HR crops also enable the farmer to incorporate reduced-or no-tillage cultural approaches more efficiently, with the elimination of environmentally toxic herbicides and reduced usage of herbicides to control weed species. Additionally, herbicide-resistant crop technology has aided the socioeconomic development of developed countries and is rapidly spreading in developing nations.