Global agriculture is under a lot of pressure due to rising population and corresponding increases in food demand and with that the emergence of several abiotic and biotic challenges, continuously affect agricultural output across the globe. One such abiotic stress that significantly lowers agricultural yield each year is drought stress along with the negative impacts from the pathogens or pest, salinity and heat. As a result, to such stress, they endure some morphological as well as physiological changes to counter the stress which includes less transpiration and photosynthetic rate, release of excess reactive oxygen species (ROS), etc. which might cause permanent damage to the respective crop. The urgent requirement is to have some situation-aware mitigating techniques. Various techniques have been described and used around the world, including various agronomic approaches, gene and biochemical cycle manipulation, and the use of plant growth promoting rhizobacteria (PGPR) to ameliorate drought stress and the present chapter includes some of the strategies related to the drought stress mitigation.