Throughout the last couple of decades, insects had caused a fatal role in damaging plants, crops and destruction of millions of agricultural lands. Our review is based on how the resistance can be incorporated against insects and pests so as to save both consumptive and non-consumptive plants along with protecting them from spreading numerous diseases to both plants and animals including human beings. Insect cytochrome P450 can also be targeted and expression by the process of monooxygenase-mediated detoxification through CYP6D1 is one novel approach towards insecticide resistance. The most commercial and experimental approach is still done through the use of Bacillus thuringiensis and its genetic engineering through different biotechnological and other process which is detrimental towards insect resistance in plants. Chemical modifications using chemical compounds like terpenes, phenols and Sulphur, nitrogen containing secondary metabolites can also be applied for insect and pest resistance but are not as effective as Bacillus thuringiensis Endotoxins and may also be prone to more side effects. Mechanism of Bacillus thuringiensis Endotoxins in insecticide resistance and its effect on soil microenvironment and humans have also been studied in this review.