In the dynamic landscape of pharmaceuticals, nanotechnology has introduced revolutionary solutions to longstanding challenges in drug delivery. Among these, nanosponges stand out as a versatile and promising platform with the potential to transform the way in administering therapeutic agents. Their unique porous structure, versatility, and ability to encapsulate a wide range of therapeutic agents make them a promising solution for enhancing drug efficacy, improving patient compliance, and reducing side effects. This review elaborates on suitability of drugs, formulation methods, evaluation, toxicity, applications and most recent developments in naonosponges.